Research topics

The main research topic of the laboratory is centered in the development of reagents and synthetic methodologies involving selenium and tellurium compounds, which could be used in the synthesis of bioactive molecules.

Among the methodologies developed by the laboratory, the most studied is the hydrotelluration of alkynes, leading to Z vinylic tellurides, which are transformed into reactive organometallics with retention of configuration by Te / M exchange.

This hydrometallation is unique in organic synthesis, as the other hydrometallations of alkynes occur in a syn fashion, giving the E organometallic. For more details about the organic chemistry of tellurium developed by the laboratory, in particular about the hydrotelluration of alkynes see:

• Comasseto, J. V.; Barrientos-Astigarraga, R E. Aldrichimica Acta 33 (2000) 66.

• COMASSETO, J. V.; VIEIRA, M. L.; ZINN, F. K. Journal of Brazilian Chemical Society 12 (2001) 586.

• Comasseto, J. V.; Clososki, G. C.; Cunha, R. L. O. R. Tellurium in: Comprehensive Organometallic Chemistry (COMC-3), vol. 9, D. M. P. Mingos; R. H. Crabtree (Eds.), Elsevier, Amsterdam (2007), pp. 587-648.

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