Research Group Page
Research direction:
The loss of proteostasis (protein homeostasis) is a hallmark of aging and is also present in several diseases. Our research group studies the regulatory pathways of proteostasis in these contexts, using the nematode Caenorhabditis elegans as a model. We are also interested in understanding how the transmission of signals from the nervous system to peripheral tissues can modulate stress response pathways, such as the unfolded protein response (UPR). To address these questions, our group employs techniques such as transcriptomics, fluorescence microscopy, and molecular biology.
Research group:
Evandro Araújo de Souza (Assistant Professor)
Maria Fernanda Kobayashi Rossi (Master student)
Pedro Kenzo Kobaiashi Forti (Undergraduate student)
Publicações selecionadas:
1) Thompson MA, De-Souza EA. Olfaction: an emerging regulator of longevity and metabolism. Trends in Cell Biology. 2024
2) Magalhaes JP, Abidi Z, Santos GA, Avelar RA, Barardo D, Chatsirisupachai K, Clark P, De-Souza EA, Johnson EJ, Lopes I, Novoa G, Senez L, Talay, Thorton D, Po To PK. Human Ageing Genomic Resources: updates on key databases in ageing research. Nucleic Acids Research. 2024
3) Vergani-Junior CA, Moro RP, Pinto S, De-Souza EA, Camara H, Braga DL, Tonon-da-Silva G, Knittel TL, Ruiz GP, Ludwig RG, Massirer KB, Mair WB, Mori MA. An Intricate Network Involving the Argonaute ALG-1 Modulates Organismal Resistance to Oxidative Stress. Nature Communications. 2024
4) De-Souza EA, Thompson MA, Taylor RC. Olfactory chemosensation extends lifespan through TGF-β signaling and UPR activation. Nature Aging. 2023 [Agência FAPESP]
5) Thompson MA, De-Souza EA. A Year at the Forefront of Proteostasis and Aging. Biology Open. 2023
6) De-Souza EA, Pimentel FSA, De-Queiroz ALFV, Camara H, Felix-Formiga ML, Machado CM, Pinto S, Galina A, Mori MA, Montero-Lomeli M, Masuda CA. The yeast protein Ubx4p contributes to mitochondrial respiration and lithium-galactose-mediated activation of the unfolded protein response. Journal of Biological Chemistry. 2020
7) De-Souza EA, Camara H, Salgueiro WG, Moro RP, Knittel TL, Tonon G, Pinto S, Forti AP, Antebi A, Pasquinelli AE, Massirer KB, Mori MA. RNA interference may result in unexpected phenotypes in Caenorhabditis elegans. Nucleic Acids Research 2019
8) Machado CM, De-Souza EA, De-Queiroz ALFV, Pimentel FSA, Silva GFS, Montero-Lomeli M, Masuda CA. The galactose-induced decrease in phosphate levels leads to toxicity in yeast models of galactosemia. BBA-Molecular Basis of Disease. 2017
9) De-Souza EA, Pimentel FSA, Machado CM, Martins LS, Da-silva WS, Montero-Lomeli M, Masuda CA. The unfolded protein response has a protective role in yeast models of classic galactosemia. Disease Models & Mechanisms. 2014
Contact: evandro@iq.usp.br
CV Lattes
ORCID
FAPESP