Research direction:
The loss of proteostasis (protein homeostasis) is one of the hallmarks of aging and is also present in several diseases. Our research group studies regulatory pathways of proteostasis in these contexts, using the nematode Caenorhabditis elegans as a model. We are also interested in understanding how signal transmission from the nervous system to peripheral tissues modulates stress-associated responses, such as the Unfolded Protein Response (UPR) of the Endoplasmic Reticulum. To answer these questions, our group employs techniques such as transcriptomics, fluorescence microscopy, and molecular biology tools. Group's website: https://sites.usp.br/evandro/
Selected publications:
1) De-Souza EA. Neurons whisper, tissues respond: neurons as orchestrators of stress responses. 2025
2) Thompson MA, De-Souza EA. Olfaction: an emerging regulator of longevity and metabolism. 2024
3) Magalhaes JP, Abidi Z, Santos GA, Avelar RA, Barardo D, Chatsirisupachai K, Clark P, De-Souza EA, Johnson EJ, Lopes I, Novoa G, Senez L, Talay, Thorton D, Po To PK. Human Ageing Genomic Resources: updates on key databases in ageing research. 2024
4) Vergani-Junior CA, Moro RP, Pinto S, De-Souza EA, Camara H, Braga DL, Tonon-da-Silva G, Knittel TL, Ruiz GP, Ludwig RG, Massirer KB, Mair WB, Mori MA. An Intricate Network Involving the Argonaute ALG-1 Modulates Organismal Resistance to Oxidative Stress. 2024
5) De-Souza EA, Thompson MA, Taylor RC. Olfactory chemosensation extends lifespan through TGF-β signaling and UPR activation. 2023 [Reportagem Agência FAPESP]
6) Thompson MA, De-Souza EA. A Year at the Forefront of Proteostasis and Aging. 2023
7) De-Souza EA, Pimentel FSA, De-Queiroz ALFV, Camara H, Felix-Formiga ML, Machado CM, Pinto S, Galina A, Mori MA, Montero-Lomeli M, Masuda CA. The yeast protein Ubx4p contributes to mitochondrial respiration and lithium-galactose-mediated activation of the unfolded protein response. 2020
8) De-Souza EA, Camara H, Salgueiro WG, Moro RP, Knittel TL, Tonon G, Pinto S, Forti AP, Antebi A, Pasquinelli AE, Massirer KB, Mori MA. RNA interference may result in unexpected phenotypes in Caenorhabditis elegans. 2019
9) Machado CM, De-Souza EA, De-Queiroz ALFV, Pimentel FSA, Silva GFS, Montero-Lomeli M, Masuda CA. The galactose-induced decrease in phosphate levels leads to toxicity in yeast models of galactosemia. 2017
10) De-Souza EA, Pimentel FSA, Machado CM, Martins LS, Da-silva WS, Montero-Lomeli M, Masuda CA. The unfolded protein response has a protective role in yeast models of classic galactosemia. 2014
Our grup was recently supported by the Instituto Serrapilheira (25/06/2025)
CV Lattes
ORCID
