Research direction:
The loss of proteostasis (protein homeostasis) is a hallmark of aging and is also present in several diseases. Our research group studies the regulatory pathways of proteostasis in these contexts, using the nematode Caenorhabditis elegans as a model. We are also interested in understanding how the transmission of signals from the nervous system to peripheral tissues can modulate stress response pathways, such as the unfolded protein response (UPR). To address these questions, our group employs techniques such as transcriptomics, fluorescence microscopy, and molecular biology.
Selected publications:
1) Thompson MA, De-Souza EA. Olfaction: an emerging regulator of longevity and metabolism. 2024
2) Magalhaes JP, Abidi Z, Santos GA, Avelar RA, Barardo D, Chatsirisupachai K, Clark P, De-Souza EA, Johnson EJ, Lopes I, Novoa G, Senez L, Talay, Thorton D, Po To PK. Human Ageing Genomic Resources: updates on key databases in ageing research. 2024
3) Vergani-Junior CA, Moro RP, Pinto S, De-Souza EA, Camara H, Braga DL, Tonon-da-Silva G, Knittel TL, Ruiz GP, Ludwig RG, Massirer KB, Mair WB, Mori MA. An Intricate Network Involving the Argonaute ALG-1 Modulates Organismal Resistance to Oxidative Stress. 2024
4) De-Souza EA, Thompson MA, Taylor RC. Olfactory chemosensation extends lifespan through TGF-β signaling and UPR activation. 2023 [Agência FAPESP]
5) Thompson MA, De-Souza EA. A Year at the Forefront of Proteostasis and Aging. 2023
6) De-Souza EA, Pimentel FSA, De-Queiroz ALFV, Camara H, Felix-Formiga ML, Machado CM, Pinto S, Galina A, Mori MA, Montero-Lomeli M, Masuda CA. The yeast protein Ubx4p contributes to mitochondrial respiration and lithium-galactose-mediated activation of the unfolded protein response. 2020
7) De-Souza EA, Camara H, Salgueiro WG, Moro RP, Knittel TL, Tonon G, Pinto S, Forti AP, Antebi A, Pasquinelli AE, Massirer KB, Mori MA. RNA interference may result in unexpected phenotypes in Caenorhabditis elegans. 2019
8) Machado CM, De-Souza EA, De-Queiroz ALFV, Pimentel FSA, Silva GFS, Montero-Lomeli M, Masuda CA. The galactose-induced decrease in phosphate levels leads to toxicity in yeast models of galactosemia. 2017
9) De-Souza EA, Pimentel FSA, Machado CM, Martins LS, Da-silva WS, Montero-Lomeli M, Masuda CA. The unfolded protein response has a protective role in yeast models of classic galactosemia. 2014
Our grup was recently supported by the Instituto Serrapilheira (25/06/2025)
CV Lattes
ORCID